Why is InsoRelief™ So Effective?

Doctor Formulation

InsoRelief™ provides a breakthrough formula that effectively combines the most powerful and extensively researched ingredients, giving you an all-in-one solution to get rid of insomnia. Every single ingredient in InsoRelief™ was hand-picked by a team of medical doctors and scientific researchers, based on clinical data and designed to help you fall asleep quicker and stay asleep longer.

InsoRelief™ contains 11 tested active ingredients that meet the strength and purity standards of the USP/NF (United States Pharmacopeia–National Formulary). Each ingredient was carefully researched and included based on clinical data. No other non-prescription solution comes close to in terms of quality and purity of ingredients.

Recommended dose for adults is 2 (two) to 4 (four) capsules at night with 8 oz of water, an hour before bedtime, as a dietary supplement. This product is to be used for general relief of insomnia, whether you have difficulty falling asleep (onset) or staying asleep (maintenance). However, caution should be taken if you have been diagnosed with chronic insomnia. Consult with your healthcare professional or a sleep specialist if your insomnia persists for more than three months. Do not exceed the recommended daily dose.

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InsoRelief™ 's - Blend of Ingredients:

    L-ornithine is an amino acid and the most important ingredient required for a natural and effective insomnia treatment. L-ornithine has the potential to relieve stress and improve sleep quality related to fatigue. InsoRelief™ is the only supplement available that is formulated with L-ornithine, making it much more effective than many other products in the market which do not contain this key ingredient.

    *References:
  1. Mika Miyake, et. al., “Randomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in healthy workers," Nutrition Journal 2014, 13:53.
  2. Sugino, T; Shirai, T; Kajimoto, Y; Kajimoto, O (2008). "L-ornithine supplementation attenuates physical fatigue in healthy volunteers by modulating lipid and amino acid metabolism". Nutrition research 28 (11): 738–43. doi:10.1016/j.nutres.2008.08.008. PMID 19083482.
  3. Valerian (Valeriana officinalis) root is extracted from a fragrant perennial flowering plant. Valerian root is believed to have sedative and anxiolytic (inhibits anxiety) effects. As such, it is an important component for inducing sleep, reducing the amount of time it takes to fall asleep and improving the quality of sleep without causing unwanted side effects common with other sleep pills or remedies.


    *References:
  4. Bent S, Padula A, Moore D, Patterson M, Mehling W (2006). "Valerian for sleep: a systematic review and meta-analysis". Am. J. Med. 119 (12): 1005–1012.
  5. Morin CM, Koetter U, Bastien C, Ware JC, Wooten V (2005). “Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial." Sleep. 28 (11): 1465-71.
  6. Chamomile is a collective term to denote several different types of daisy-like plants. Chamomile is considered a safe plant for digestion and has been used for centuries in traditional medicine as a mild sedative and to calm anxiety. Chamomile soothing effects have long been touted for general health and wellbeing.


    *References:
  7. Singh, O; Khanam, Z; Misra, N; Srivastava, MK (January 2011). "Chamomile (Matricaria chamomilla L.): An overview.". Pharmacognosy reviews 5 (9): 82–95. doi:10.4103/0973-7847.79103. PMC 3210003. PMID 22096322.
  8. Srivastava, JK; Shankar, E; Gupta, S (2010). “Chamomile: A herbal medicine of the past with bright future". Molecular medicine reports 3 (6): 895–901.
  9. Passionflower (Passiflora incarnata) Extract is often used as an anti-anxiety agent, an anti-depressant and a sleep-inducing agent. It is known for its relaxing and calming properties.


    *References:
  10. Dhawan K, Kumar S, Sharma A. Anti-anxiety studies on extracts of Passiflora incarnata Linneaus. J Ethnopharmacol 2001;78:165-70.
  11. Miyasaka LS, Atallah AN, Soares BG. Passiflora for anxiety disorder. Cochrane Database Syst Rev 2007;(1):CD004518.
  12. Lemon Balm (Melissa officinalis) Extract, when combined with other calming herbs (such as valerian, hops, and chamomile) helps reduce anxiety and promote sleep. Several studies also demonstrate the sedative qualities of lemon balm and improving the quality of sleep.


    *References:
  13. Kennedy DO, Little W, Haskell CF, Scholey AB. Anxiolytic effects of a combination of Melissa officinalis and Valeriana officinalis during laboratory induced stress. Phytother Res. 2006;20(2):96-102.
  14. Muller SF, Klement S. A combination of valerian and lemon balm is effective in the treatment of restlessness and dyssomnia in children. Phytomedicine. 2006;13(6):383-7.
  15. Hops (Humulus lupulus) Flower is a perennial fragrant plant and is known for its ability to induce sleep. Research suggests that a combination of Hops Extract in addition to Valerian Extract at bedtime helps some people fall asleep faster and also improves the quality of sleep. Not only does it provoke sleep, but it also eases excessive irritability and anxiety, which are common causes for insomnia.


    *References:
  16. Franco L, Sánchez C, Bravo R, Rodriguez A, Barriga C, Juánez JC; Sánchez; Bravo; Rodriguez; Barriga; Juánez (June 2012). "The sedative effects of hops (Humulus lupulus), a component of beer, on the activity/rest rhythm". Acta Physiologica Hungarica 99(2): 133–9.
  17. Morin CM, Koetter U, Bastien C, Ware JC, Wooten V (2005). “Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial." Sleep. 28 (11): 1465-71.
  18. Taurine is an amino acid that supports neurological development and helps calm the central nervous system by activating the glycine receptor. Taurine can help manage stress by lowering cortisol levels which can assist people in sleeping more soundly.


    *References:
  19. Chen, SW; Kong, WX; Zhang, YJ; Li, YL; Mi, XJ; Mu, XS (2004). "Possible anxiolytic effects of taurine in the mouse elevated plus-maze". Life Sciences 75 (12): 1503–11.
  20. Green, TR; Fellman, JH; Eicher, AL; Pratt, KL (1991). "Antioxidant role and subcellular location of hypotaurine and taurine in human neutrophils". Biochimica et Biophysica Acta 1073 (1): 91–7.
  21. Magnolia (Magnolia officinalis) Bark is used in traditional Chinese medicine for many different ailments. Much like Taurine, Magnolia Bark can help manage stress by lowering cortisol levels which assists people in sleeping more soundly.

    *References:
  22. Kalman D.S., Feldman S., Feldman R., Schwartz H.I., Krieger D.R., Garrison R. (2008). "Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: A pilot, double-blind, placebo-controlled clinical trial". Nutrition Journal 7 (1): 11. doi:10.1186/1475-2891-7-11.
  23. Talbott, Shawn M. et al. “Effect of Magnolia officinalis and Phellodendron amurense (Relora) on cortisol and psychological mood state in moderately stressed subjects." Journal of the International Society of Sports Nutrition. 2013; 10(37).
  24. Jujube Extract (Zyzyphus jujube) Seed is a plant which bears fruit and seeds that are widely used in traditional Chinese and Korean medicines. Many suggest that this unique plant possess anxiety-reducing and sedative properties.


    *References:
  25. Jiang J.-G., Huang X.-J., Chen J., Lin Q.-S.,"Comparison of the sedative and hypnotic effects of flavonoids, saponins, and polysaccharides extracted from Semen Ziziphus jujube", Natural Product Research 2007 21:4 (310-320).
  26. Mahajan R.T., Chopda M.Z. "Phyto-pharmacology of Ziziphus jujuba mill - A plant review" Mahajan R.T., Chopda M.Z. Pharmacognosy Reviews 2009 3:6 (320–329).
  27. Reishi mushroom (Ganoderma lucidum) has been widely used in traditional Chinese medicine to treat many ailments. Research has indicated that Reishi mushrooms are believed to contain anxiolytic-like effects. As such, it is an important component for inducing sleep.


    *References:
  28. Dinesh, P. Babu and Subhasree, R.S. (2008). The Sacred Mushroom "Reishi" - a Review. American - Eurasian Journal of Botany, 1 (3): 107-110.
  29. Socala, K. (2015). "Evaluation of Anticonvulsant, Antidepressant-, and Anxiolytic-like Effects of an Aqueous Extract from Cultured Mycelia of the Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Higher Basidiomycetes) in Mice.". Int J Med Mushrooms 17 (3): 209–18.
  30. Melatonin is nature's "sleep hormone". It controls the normal sleep-wake cycle and has been reported to help reduce the time needed to fall asleep and affects how long you stay asleep. Its production levels vary throughout our life cycle differing between newborns, teenagers and old age, these differing levels affect our sleep patterns. Studies have shown that prolonged-release melatonin improves sleep quality providing a healthier, more refreshing sleep than sedative drugs.


    *References:
  31. Buscemi N, Vandermeer B, Hooton N, et al. The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis. J Gen Intern Med 2005;20:1151-8.
  32. Haimov I, Laudon M, Zisapel N, Souroujon M, Nof D, Shlitner A, et al. Sleep disorders and melatonin rhythms in elderly people. BMJ 1994;309:167.